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SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Pro
日期: 2020-09-01 18:52 浏览: 987

Our previous studies revealed that the downregulation of Suppressor of cytokine signaling 6 (SOCS6) was correlated with malignant progression of human prostate cancer (PCa). In thecurrent study, we aimed to investigate the tumor suppressive roles of SOCS6 and the underlyingmechanisms in PCa. SOCS6 expression in PCa and non-cancerous prostate tissues was compared by immunohistochemistry. Statistical associations of SOCS6 expression with various clinicopathological features and patients' prognosis were evaluated. In addition, we investigated SOCS6’s functionsby overexpressing it in vitro (cell apoptosis, migration and invasion assays) and in vivo (tumor formation, angiogenesis and apoptosis).Moreover, SOCS6-regulated genes were identified by nextgeneration RNA-sequencing analysis, followed by pathway enrichment analysis and in vitro experimental validation.SOCS6 downregulation was significantly associated with advanced clinicalstage (P=0.029) and positive lymph node metastasis (P=0.013)in PCa patients. We also identifiedSOCS6 as an independent prognostic factor for disease-free survival in PCa patients (P=0.045).Moreover, overexpression of SOCS6 inhibited PCa cell invasion, migration, tumor xenograftsgrowth and angiogenesis, but induced PCa cell apoptosis (P values